Evidence for the use of helminthic therapy
to treat Multiple Sclerosis
Multiple Sclerosis is well-researched with respect to helminthic therapy. There are numerous animal studies and one landmark paper (see below) clearly demonstrating the potential benefits of using almost any helminth to slow or arrest the progress of relapsing remitting multiple sclerosis in humans. This remarkable study was conducted using powerful tools (MRI, sophisticated blood analysis), rigorous methods (control group, peer-reviewed) and took more than four and one half years to complete before publication in one of the world's leading scientific journals (the American Annals of Neurology). It's results are unequivocal and stunning: helminthic therapy is will slow or arrest the course of relapsing remitting multiple sclerosis, apparently in everyone who tries it.
Helminthic therapy is based on the Hygiene Hypothesis and science. This is not an alternative therapy, it is an experimental treatment being investigated in the worlds' leading laboratories. Helminths are a very powerful probiotic. Instead of relying on powerful drugs targeting your immune system it provides your immune system what it needs to work better and to stop attacking your nerves.
Despite our confidence in what we offer it has to be noted that our approach is experimental. It is not sanctioned by any national health authority such as the FDA or EMEA and for that reason, although we require that your doctor be informed of your choice with respect to using this approach, no doctor is able to recommend helminthic therapy.
Helminthic therapy as an approach to treating relapsing remitting multiple sclerosis has not been proven in the laboratory to the level that drugs are before being made available. Treatment is only provided after an extensive evaluation period and interview, and formal acceptance of our Client Agreement.
Treatment is self-administered at home by the majority of our clients. It is shipped to your home for self application. We guarantee the probiotic organisms will remain alive within you for at least the low end of their life span, three years for hookworm, the organism of choice for Multiple Sclerosis in most cases.
We encourage you to research this approach extensively before making a decision, this site is dedicated to helping you do that, but there are many more resources online available by searching for "helminth multiple sclerosis" or "hygiene hypothesis multiple sclerosis". Clicking on either quoted search term will take you to a Google search page for those search terms.
For a copy of the full text of any papers here, and many others, please contact us being sure to name the disease, or subject, you would like the papers to investigate.
Objective: To assess whether parasite infection is correlated with a reduced number of exacerbations and altered immune reactivity in multiple sclerosis (MS)
Methods: A prospective, double-cohort study was performed to assess the clinical course and radiological findings in 12 MS patients presenting associated eosinophilia. All patients presented parasitic infections with positive stool specimens. In all parasite-infected MS patients, the eosinophilia was not present during the 2 previous years. Eosinophil counts were monitored at 3- to 6-month intervals. When counts became elevated, patients were enrolled in the study. Interleukin (IL)-4, IL-10, IL-12, transforming growth factor (TGF)-, and interferon- production by myelin basic protein-specific peripheral blood mononuclear cells were studied using enzyme-linked immunospot (ELISPOT). FoxP3 and Smad7 expression were studied by reverse-transcriptase polymerase chain reaction.
Results: During a 4.6-year follow-up period, parasite-infected MS patients showed a significantly lower number of exacerbations, minimal variation in disability scores, as well as fewer magnetic resonance imaging changes when compared with uninfected MS patients. Furthermore, myelin basic protein-specific responses in peripheral blood showed a significant increase in IL-10 and TGF-Beta and a decrease in IL-12 and interferon--secreting cells in infected MS patients compared with noninfected patients. Myelin basic protein-specific T cells cloned from infected subjects were characterized by the absence of IL-2 and IL-4 production, but high IL-10 and/or TGF-Beta secretion, showing a cytokine profile similar to the T-cell subsets Tr1 and Th3. Moreover, cloning frequency of CD4+CD25+ FoxP3+ T cells was substantially increased in infected patients compared with uninfected MS subjects. Finally, Smad7 messenger RNA was not detected in T cells from infected MS patients secreting TGF-Beta.
Interpretation: Increased production of IL-10 and TGF-Beta, together with induction of CD25+CD4+ FoxP3+ T cells, suggests that regulatory T cells induced during parasite infections can alter the course of MS. PMID: 17230481
Abstract: Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS) characterized by chronic inflammatory demyelination of the central nervous system (CNS). The pathology of EAE involves autoimmune CD4+ Th1 cells. There is a striking inverse correlation between the occurrence of parasitic and autoimmune diseases. We demonstrate that in mice with Schistosoma mansoni ova immunization, the severity of EAE is reduced as measured by decreased clinical scores and CNS cellular infiltrates. Disease suppression is associated with immune deviation in the periphery and the CNS, demonstrated by decreased IFN-g and increased IL-4, transforming growth factor-b and IL-10 levels in the periphery, and increased frequency of IL-4 producing neuroantigen-specific T cells in the brain. S. mansoni helminth ova treatment influenced the course of EAE in wild-type mice, but not in STAT6-deficient animals. This indicates that STAT6 plays a critical role in regulating the ameliorating effect of S. mansoni ova treatment on the autoimmune response, and provides the direct link between helminth treatment, Th2 environment and improved EAE. As some intestinal helminthic infections induce minimal pathology, they might offer a safe and inexpensive therapy to prevent and/or ameliorate MS. Full Text Available for Free Download
Abstract: A preestablished infection with the parasitic helminth, Schistosoma mansoni, significantly reduced the incidence and delayed the onset of experimental autoimmune encephalomyelitis (EAE) in mice. The altered disease progression was not solely due to the induction of a strong Th2 response, since intraperitoneal injection of schistosome eggs did not affect disease development. MOG-specific gamma interferon (IFN-G), nitric oxide, and tumor necrosis factor alpha production by splenocytes was significantly reduced in schistosome-infected mice compared to uninfected mice. However, similar levels of interleukin-10 (IL-10) were produced in an antigen-specific manner, suggesting that the induction of antigen-specific responses was not inhibited. Analysis of in vivo cytokine production by real-time PCR indicated that IL-12p40, but not IFN-G, transcript levels were dramatically reduced in the spinal cords of schistosome-infected, MOG-immunized mice. Furthermore, analysis of the cellular composition of the spinal cords and brains revealed that a preestablished infection with S. mansoni decreased central nervous system (CNS) inflammation, particularly of macrophages and CD4 T cells. These results suggest that schistosomiasis may negatively regulate the onset of EAE by down-regulating the production of proinflammatory cytokines and altering CNS inflammation. Full Text Available for Free Download.
To protect the privacy of our clients we use pseudonyms unless given permission in writing to do otherwise. For the first account, although our client's name is changed, he has asked that we provide his telephone number and email address.
When I was in my teens I began to have symptoms of multiple sclerosis (numbness, dizziness, fatigue). I was officially diagnosed with Multiple Sclerosis in the fall of 1995 at the age of 41 by two doctors - including a board certified Neurologist. After starting a low saturated fat diet in late 1995, my multiple sclerosis diminished in severity, and was limited to flares in the fall and spring.
I regularly had blood tests and physicals by a neurologist to keep track of my condition.
Late in 2000 my yearly blood tests showed that Sjogren's Specific Antibody tests and Anti-Nuclear Antibodies began to rise though they were in the normal ranges. Unfortunately, two years later the test results and my physical symptoms led to the diagnosis by a Rheumatologist that I had Sjogren's Syndrome as well as having multiple sclerosis.
After developing full blown Sjogren’s Syndrome in 2002, my twice yearly multiple sclerosis flares became more, and more intense (though thankfully I developed no new multiple sclerosis symptoms). By 2007, my multiple sclerosis flares had become periodically disabling because of overwhelming fatigue. I had to be in bed for 4-6 weeks twice a year for 18-24 hours a day due to this intense fatigue. For many additional weeks I needed to be in a recliner to rest for many hours each day.
In early 2007, I became intrigued by several medical journal articles on research that dealt with the idea that rise in modern autoimmune disorders may be related to the elimination of helminths in humans in the early 19th and 20th century: the hygiene hypothesis
The research being done at universities around the world indicated that by infecting people with small, benign doses of helminths, many difficult to treat autoimmune disorders either greatly improved or were put into remission.
With multiple sclerosis, I was being asked by my MD to try Betaseron or some other disease modifying drug for multiple sclerosis. Betaseron has a large number of potentially dangerous side effects. so I was reluctant to do so as I had had no new symptoms for a decade. Plus, I had heard horror stories of high-school class mates who have multiple sclerosis as well, and had major problems with these medicines.
The results using helminths at universities were spectacular for a number of autoimmune diseases. The research being done at universities around the world indicated that by infecting people with small, benign doses of helminths, many difficult to treat autoimmune disorders either greatly improved or were put into remission.
The thinking behind these results was that low levels of helminths helped autoimmune disease because the human immune system evolved to be "normal" in the presence of helminths. These helminths have been with all humans for the hundreds of thousands of years of human existence. They were even probably with our genetic ancestors. Without these helminths being present many people's immune systems cannot function properly. This is because people evolved with immune systems that required the presence of normal flora and fauna of the gut, and because of antibiotics, cleaner living conditions, etc., this was no longer present (helminths).
For me, I decided that the risks associated with getting inoculated with hookworms (helminthic therapy as it is now known) were very minimal. If the treatment worked, I could obtain important gains in the quality of my life. The hookworms were easy to get rid of if I decided that I did not benefit from them. The financial risk was the only real risk I could see and compared to what I was suffering this seemed to me to be a very small risk. So I contacted Jasper at Autoimmune Therapies and was inoculated with hookworm on September 26, 2007.
My Sjogren’s Syndrome was greatly improved by the inoculation of hookworms, but I received a very welcome bonus from the hookworm treatment- a great improvement in multiple sclerosis flares and the related fatigue and neurological symptoms. With the hookworms present, my flares were limited to a 2-4 weeks of rest for 12-16 hours a day- much of it in a recliner instead of being confined to my bed around the clock. The feeling of being overwhelmed by fatigue was greatly diminished. I would say that I had a 50-80% improvement in my multiple sclerosis flares from the inoculation.
To me, this has been a Godsend! I am able to still have a life during the multiple sclerosis flares which I largely lost with the onset of Sjogren’s Syndrome. Additionally, I have had a similar reduction in the duration and intensity in the return of the old neurological symptoms that I had in the mid 1990's. Jasper explained to me before treatment that hookworm could only stop the disease from progressing, that it could not undo the permanent scarring and tissue damage.
My side effects from the first 20 larvae inoculation was mainly itching (controlled with oral and topical antihistamines like benadryl) a day and a half of flu-like symptoms, followed by a few weeks of on-and-off gas and slight fatigue. I did not have any side effects, as Jasper had predicted, with subsequent inoculations.
My main benefits were in the area of Sjogren’s Syndrome (see my Sjogren’s Syndrome account). It has erased years off the progress of the Sjogren’s Syndrome, but the benefit to my multiple sclerosis has been substantial and welcome!
I am happy to discuss my experience with the hookworm inoculation- just call my phone (below) and mention hookworms. If I do not answer, leave your number and I will try to get back to you ASP. (Editor's note: please contact us for "Cal's" contact information)
My best wishes for your good health!
(Please note that I am on Pacific Time, or GMT -8 hours)
At age 35 years I was in perfect health, at the top of my career and leading a very active lifestyle.
Early February 2003 I had a sudden MS attack and was given a diagnosis of Multiple Sclerosis, completely paralysed from the neck down.
I consider myself lucky to some degree, my type of MS is Relapsing Remitting which means the body repairs itself but is susceptible to further attacks.
So far and with time I've recovered nearly completely after each attack, just experiencing residual damage.
I have experienced an attack every year around April-May like clock work since my first attack, until this year.
Here's a brief history of my MS attacks which required hospitalisation, of which I also have records and MRI scans.
First attack 2003 complete paralysis neck down.
Second attack 2004 limited use upper arms
Third attack 2005 vision loss
Fourth attack 2006 unable to lift left leg
Fifth attack 2007 unable to regulate body temperature
Attack Free 2008
Since the beginning of my MS I have always eaten a very healthy Low fat diet, exercised daily, and taken nutritional supplements - fish oil, evening primrose oil and a good multivitamin. MS Therapies tried thus far: Betaferon (Beta Interferon), Copaxone, Minocycline and Low Dose Naltrexone. Although these therapies work well for some, and more than likely helps slow the progression, I continued to have my annual attacks and my MRI scans showed activity.
After watching a BBC documentary showing low incidents of autoimmune conditions in Africa amongst those infected with helminths (parasitic worms), headed up by Dr. Weinstock and his experiments with TSO (Trichuris Suis Ova), I dug deeper and came across Autoimmune Therapies headed up by Jasper Lawrence.
I was part of the first group to receive helminthic therapy in the form of hookworms From Autoimmune Therapie's Tijuana clinic on September 25, 2007, Since my first inoculation I've been inoculated with a total of 100 hookworms.
Although this appears to have stopped my multiple sclerosis from getting any worse, as Jasper predicted it has not repaired the damage done up to this point. During the time of my annual MS attack I still experienced very light exacerbations of old MS symptoms which is a reminder that my MS is still present however under control. My hope is that over the next twelve months I will be free of the exacerbations as well. But, my MS is not getting any worse, and this year for the first time I had no terrible experience with paralysis or vision loss. Fantastic.
Also I would like to point out my hay fever and allergies are 100 percent gone!
So far so good!